BIO 409 Molecular Developmental Biology
The following figures were discussed in class and published in the journal DEVELOPMENT.
The original articles can be found in the Life Science Library.
"msd is required for mesoderm induction in mice"
Bernadette C. Holdener, Cynthia Faust, Nancy S. Rosenthal, and Terry Magnuson
Development 120, 1335-1346, 1994
Figure 2. Comparison of msd embryos with normal littermates.
Figure 3. Gene expression in msd embryos.
Figure 4. Gene expression in msd embryos.
Figure 5. Gene expression in msd embryos.
The eed mutation disrupts anterior mesoderm production in mice
Cynthia Faust, Armin Schumacher, Bernadette Holdener, and Terry Magnuson
Development 121m 274-285, 1995
Figure 1.The eed phenotype
Figure 2.Analysis of proximal primitive streak function
Figure 3.Analysis of distal primitive streak function
Figure 4.Axial mesoderm is specified in eed mutant embryos
Figure 5.nodal is inappropriately expressed in eed mutant embryos
Figure 6.T and Evx1 are ectopically expressed in eed mutant embryos.
A Primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
Frank L. Conlon, Karen M. Lyons, Norma Takaesu, Katrin S. Barth, Andreas Kispert, Bernhard
Herrman, and Elizabeth J. Robertson
Development 120, 1919-1928, 1994
Figure 2.Morphology of wild-type and 413.d mutantembryos
Figure 3.Expression of nodal and goosecoid RNA
Figure 4. Nodal is expression at the late streak stage
Figure 5.Expression of sox-2 mRNA and T protein
Figure 6.Expression of T, cdx-4 and Mox-1 protein
A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral insertion. Frank L. Conlon and Elizabeth J. Robertson
Development 111, 969-981, 1991
The following figures compare msd, 413.d, and eed mutant phenotypes.
Comparison of mutant phenotypes.
Comparison of T gene expression in mutant embryos