BIO 409 Molecular Developmental Biology

The following figures were discussed in class and published in the journal DEVELOPMENT.

The original articles can be found in the Life Science Library.

"msd is required for mesoderm induction in mice" Bernadette C. Holdener, Cynthia Faust, Nancy S. Rosenthal, and Terry Magnuson Development 120, 1335-1346, 1994

  • Figure 2. Comparison of msd embryos with normal littermates.
  • Figure 3. Gene expression in msd embryos.
  • Figure 4. Gene expression in msd embryos.
  • Figure 5. Gene expression in msd embryos.


    The eed mutation disrupts anterior mesoderm production in mice Cynthia Faust, Armin Schumacher, Bernadette Holdener, and Terry Magnuson Development 121m 274-285, 1995


  • Figure 1.The eed phenotype
  • Figure 2.Analysis of proximal primitive streak function
  • Figure 3.Analysis of distal primitive streak function
  • Figure 4.Axial mesoderm is specified in eed mutant embryos
  • Figure 5.nodal is inappropriately expressed in eed mutant embryos
  • Figure 6.T and Evx1 are ectopically expressed in eed mutant embryos.

    A Primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse Frank L. Conlon, Karen M. Lyons, Norma Takaesu, Katrin S. Barth, Andreas Kispert, Bernhard Herrman, and Elizabeth J. Robertson Development 120, 1919-1928, 1994


  • Figure 2.Morphology of wild-type and 413.d mutantembryos
  • Figure 3.Expression of nodal and goosecoid RNA
  • Figure 4. Nodal is expression at the late streak stage
  • Figure 5.Expression of sox-2 mRNA and T protein
  • Figure 6.Expression of T, cdx-4 and Mox-1 protein

    A novel retrovirally induced embryonic lethal mutation in the mouse: assessment of the developmental fate of embryonic stem cells homozygous for the 413.d proviral insertion. Frank L. Conlon and Elizabeth J. Robertson Development 111, 969-981, 1991


  • 413.c tumors


    The following figures compare msd, 413.d, and eed mutant phenotypes.

  • Comparison of mutant phenotypes.
  • Comparison of T gene expression in mutant embryos

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    Modified APRIL 3rd, 1996 by S. Schram